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pentobarbital will decrease the level or outcome of ambrisentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.pentobarbital will lessen the level or impact of norgestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Moderate CYP3A4 inducers may well de